Impact of multiplicity of functional KIR-HLA compound genotypes on hepatocellular carcinoma
نویسندگان
چکیده
Natural killer (NK) cells are potential immune components against hepatocellular carcinoma (HCC) after curative hepatectomy. Patients at high risk of HCC recurrence can be identified by quantifying NK cell licensing. Therefore, therapeutic strategies that manipulate NK cell activity may possibly improve the prognosis of HCC patients.
منابع مشابه
Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy.
Natural killer (NK) cells have a potential role in immune surveillance of hepatocellular carcinoma (HCC). Self-recognition of human leukocyte antigens (HLA) through killer immunoglobulin-like receptors (KIR) confers competence to NK cells-a process termed "licensing." We investigated the effect of NK-cell licensing on the susceptibility of patients to HCC recurrence. A total of 170 Japanese pat...
متن کاملارتباط برهمکنشهای KIR-HLA با بیماریها
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors which control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. H...
متن کاملHLA and killer immunoglobulin-like receptor genes as outcome predictors of hepatitis C virus-related hepatocellular carcinoma.
PURPOSE We evaluated the impact of the killer immunoglobulin-like receptors (KIR) of natural killer (NK) cells and of their HLA ligands over the clinical outcome of hepatitis C virus (HCV)-related hepatocellular carcinoma after curative treatment by either surgical resection or radiofrequency thermal ablation (RTA). EXPERIMENTAL DESIGN Sixty-one consecutive patients with HCV-related hepatocel...
متن کاملHLA-KIR Interactions and Immunity to Viral Infections
Host genetic factors play a central role in determining the clinical phenotype of human diseases. Association between two polymorphic loci in human genome, human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptors (KIRs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. Hence, defining the influence of genetic di...
متن کاملHuman Leukocyte Antigen and Killer Immunoglobulin-like receptor genes as outcome predictors of hepatitis C virus-related hepatocellular carcinoma
Purpose: We evaluated the impact of the Killer Immunoglobulin-like Receptors (KIRs) of natural killer (NK) cells and of their Human Leukocyte Antigen (HLA) ligands over the clinical outcome of HCV-related hepatocellular carcinoma (HCC) after curative treatment by either surgical resection (SR) or radiofrequency thermal ablation (RTA). Experimental Design: Sixty-one consecutive patients with HCV...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2015